The International Conference on “Current Challenges in Occupational and Environmental Health” held at Maulana Azad Medical College from 28–30 November 2023, brought together experts to address critical issues in air and water pollution, climate change, workplace safety, and occupational health. Key themes included environmental exposures, genetic interactions, mental health, and emerging technologies like AI in health monitoring. Discussions emphasized the unorganized sector’s challenges, the need for skilled manpower, and community engagement. The event highlighted research gaps, proposed innovative solutions, and called for stronger policies and intersectoral collaboration to promote safer, healthier environments and workplaces.